Sporadic cerebral small vessel disease (cSVD) is primarily attributed to heritability and vascular risk factors.Still, our understanding of the causative factors in cSVD lesion burden in the brain is far from complete.This is exemplified by this case of identical twins with remarkably similar vascular Cappuccino Cups risk profiles, where one twin h
The function of AarF domain-containing kinase 1 (ADCK1) has not been thoroughly revealed.Here we identified that ADCK1 utilizes YME1-like 1 ATPase (YME1L1) to control optic atrophy 1 (OPA1) and inner membrane mitochondrial protein (IMMT) in regulating mitochondrial dynamics and cristae structure.We firstly observed rescue tool that a serious develo
Traumatic optic neuropathy (TON) is a condition that causes massive loss of retinal ganglion cells (RGCs) and their axonal fibers, leading to visual insufficiency.Several intrinsic and external factors Cleavers can limit the regenerative ability of RGC after TON, subsequently resulting in RGC death.Hence, it is important to investigate a potential